Map3k14 Gene Summary [Mouse]
Enables protein serine/threonine kinase activity. Involved in immune response and non-canonical NF-kappaB signal transduction. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; sensory organ; and skeleton. Used to study Sjogren's syndrome and primary biliary cholangitis. Human ortholog(s) of this gene implicated in immunodeficiency 112. Orthologous to human MAP3K14 (mitogen-activated protein kinase kinase kinase 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map3k14 |
| Official Name | mitogen-activated protein kinase kinase kinase 14 [Source:MGI Symbol;Acc:MGI:1858204] |
| Ensembl ID | ENSMUSG00000020941 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 14 |
| Synonyms | aly, FTDCR1B, HS, HSNIK, IMD112, mitogen-activated protein kinase kinase kinase 14, NFKB INDUCING KINASE, nf κ b inducing kinase, NIK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Map3k14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RGG domain
- protein serine/threonine kinase
- protein kinase
- catalytic domain
- serine/threonine kinase domain
- TRAF3-binding domain
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- nucleotide-binding domain
- kinase domain
- leucine-rich repeat
- TRAF binding domain
- Protein Kinases, catalytic domain
- IKK binding domain
Pathways
Biological processes and signaling networks where the Map3k14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Acute Phase Response Signaling
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Apoptosis Signaling
- April Mediated Signaling
- B Cell Activating Factor Signaling
- B Cell Receptor Signaling
- Cardiac Hypertrophy Signaling
- CD27 Signaling in Lymphocytes
- CD40 Signaling
- Death Receptor Signaling
- Dendritic Cell Maturation
- Ephrin Receptor Signaling
- G-Protein Coupled Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Glucocorticoid Receptor Signaling
- GNRH Signaling
- Hepatic Cholestasis
- HGF Signaling
- IL-1 Signaling
- LPS-stimulated MAPK Signaling
- NF-κB Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- plasma cell myeloma
- COVID-19
- experimental autoimmune encephalomyelitis
- osteolysis
- NIK deficiency
- eosinophilia
- insulin-dependent diabetes mellitus
- chronic autoimmune hepatitis
- osteoporosis
phenotypes
- abnormal B cell activation
- abnormal B cell physiology
- abnormal CD4-positive CD25-positive alpha-beta regulatory T cell morphology
- abnormal NK T cell morphology
- abnormal T cell activation
- abnormal bile duct morphology
- abnormal class switch recombination
- abnormal dendritic cell antigen presentation
- abnormal dendritic cell physiology
- abnormal hepatobiliary system morphology
- abnormal immune system morphology
- abnormal immune system physiology
- abnormal intestinal epithelium morphology
- abnormal intestinal goblet cell morphology
- abnormal lymphocyte morphology
- abnormal lymphopoiesis
- abnormal mammary fat pad morphology
- abnormal mammary gland development
- abnormal salivary gland morphology
- abnormal spleen B cell follicle morphology
- abnormal spleen marginal zone morphology
- abnormal spleen morphology
- abnormal spleen primary B follicle morphology
- abnormal thymus cell ratio
- abnormal thymus corticomedullary boundary morphology
- abnormal thymus medulla morphology
- abnormal thymus morphology
- absent Peyer's patches
- absent axillary lymph nodes
- absent cervical lymph nodes
- absent follicular dendritic cells
- absent inguinal lymph nodes
- absent lymph nodes
- absent mesenteric lymph nodes
- absent popliteal lymph nodes
- absent spleen marginal zone
- absent thymus corticomedullary boundary
- arrested B cell differentiation
- bile duct hyperplasia
- bile duct inflammation
- bile duct proliferation
- decreased B cell number
- decreased B-2 B cell number
- decreased IgA level
- decreased IgE level
- decreased IgG level
- decreased IgG2b level
- decreased IgM level
- decreased NK T cell number
- decreased circulating interferon-gamma level
- decreased circulating interleukin-4 level
- decreased dendritic cell number
- decreased follicular B cell number
- decreased germinal center B cell number
- decreased immunoglobulin level
- decreased mammary fat pad weight
- decreased marginal zone B cell number
- decreased mast cell number
- decreased regulatory T cell number
- decreased transitional stage T1 B cell number
- decreased transitional stage T2 B cell number
- dilated bile duct
- increased eosinophil cell number
- increased inflammatory response
- increased length of allograft survival
- increased susceptibility to infection
- increased susceptibility to parasitic infection
- kidney inflammation
- lacrimal gland inflammation
- liver inflammation
- lung inflammation
- pancreas inflammation
- premature death
- small axillary lymph nodes
- small brachial lymph nodes
- small thymus
- thymus cysts
role in cell
- expression in
- activation
- migration
- cell death
- activation in
- proliferation
- apoptosis
- growth
- production in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- fibrillar center
- intracellular membrane-bounded organelle
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Map3k14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- cellular response to mechanical stimulus
- immune response
- NIK/NF-kappaB cascade
- defense response to virus
- I-kappaB kinase/NF-kappaB cascade
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- MAP kinase kinase kinase activity
- protein serine/threonine kinase activity