Dnajc24 Gene Summary [Mouse]
Predicted to enable ATPase activator activity; ferrous iron binding activity; and zinc ion binding activity. Involved in protein histidyl modification to diphthamide. Is active in actin cytoskeleton. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human DNAJC24 (DnaJ heat shock protein family (Hsp40) member C24). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnajc24 |
| Official Name | DnaJ heat shock protein family (Hsp40) member C24 [Source:MGI Symbol;Acc:MGI:1919522] |
| Ensembl ID | ENSMUSG00000027166 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member C24 |
| Synonyms | 1700030A21Rik, 2610027M02Rik, DnaJ heat shock protein family (Hsp40) member C24, DPH4, JJJ3, MmDjC7, RGD1564710, ZCSL3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnajc24 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron binding
- DnaJ domain
- ATPase stimulator
- DnaJ
- DnaJ molecular chaperone homology domain
- zinc ion binding
- CSL zinc finger
Pathways
Biological processes and signaling networks where the Dnajc24 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- glaucoma
- idiopathic scoliosis
- gout
regulated by
- bucladesine
role in cell
- proliferation
- phosphorylation in
- apoptosis
- migration
- cell viability
- colony formation by
- invasion by
- downregulation in
- diphthamidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- actin cytoskeleton
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnajc24 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-diphthamide biosynthetic process from peptidyl-histidine
- positive regulation of ATPase activity
- chaperone-mediated protein folding
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- ferrous iron binding
- ATPase activator activity