Hmgxb4 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Predicted to be part of NURF complex. Is expressed in several structures, including aorta; central nervous system; early conceptus; gonad; and thymus. Orthologous to human HMGXB4 (HMG-box containing 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmgxb4 |
| Official Name | HMG box domain containing 4 [Source:MGI Symbol;Acc:MGI:1918073] |
| Ensembl ID | ENSMUSG00000034518 |
| Bio databases IDs | |
| Aliases | HMG box domain containing 4 |
| Synonyms | 4733401K04Rik, HMG2L1, Hmgb2l1, HMGBCG, HMG-box containing 4, HMG box domain containing 4, P53N, THC211630 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hmgxb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- high mobility group (HMG)-box domain superfamily
- HMG (high mobility group) box
- high mobility group
- Domain of unknown function (DUF4171)
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endotoxin shock response
- acute lung injury
regulated by
- lipopolysaccharide
- WNT3A
- (R)-3-hydroxybutyric acid
- topotecan
- garcinol
role in cell
- expression in
- production in
- cell-cell adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hmgxb4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Wnt receptor signaling pathway
- endosome to lysosome transport
- negative regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- NURF complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein binding