Caprin1 Gene Summary [Mouse]
Predicted to enable several functions, including ATP binding activity; molecular condensate scaffold activity; and signaling adaptor activity. Involved in positive regulation of dendritic spine morphogenesis. Acts upstream of or within generation of neurons; intracellular mRNA localization; and synapse assembly. Located in cytoplasmic stress granule. Is active in dendrite and synapse. Is expressed in central nervous system; eye; and genitourinary system. Orthologous to human CAPRIN1 (cell cycle associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Caprin1 |
| Official Name | cell cycle associated protein 1 [Source:MGI Symbol;Acc:MGI:1858234] |
| Ensembl ID | ENSMUSG00000027184 |
| Bio databases IDs | |
| Aliases | cell cycle associated protein 1 |
| Synonyms | cell cycle associated protein 1, CONDCAC, Gp137, Gpiap, GPIAP1, GPIP137, GRIP137, M11S1, Mmgpip137, NEDLAAD, P137, p137GPI, RNG105 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Caprin1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Caprin-1 dimerization domain
- Cytoplasmic activation/proliferation-associated protein-1 C term
- mRNA binding
- ATP binding
- protein binding activity, bridging
- protein binding
- translation regulator
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neurodevelopmental disorder with language impairment, autism, and attention deficit-hyperactivity disorder
- juvenile myoclonic epilepsy
- pancreatic cancer
- Moyamoya disease
- nasopharyngeal carcinoma
- nasopharyngeal cancer
- cyanosis
- childhood-onset neurodegeneration with cerebellar ataxia and cognitive decline
- glioblastoma
role in cell
- expression in
- apoptosis
- formation in
- proliferation
- function
- assembly
- formation
- generation
- replication in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cytoplasmic mRNA processing body
- organelle
- cell surface
- postsynaptic region
- cellular membrane
- ribosome
- Nucleus
- granules
- cytosol
- synapse
- stress granule
- cell membrane leading edge
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Caprin1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of dendritic spine morphogenesis
- synapse assembly
- intracellular mRNA localization
- generation of neurons
- negative regulation of translation
- positive regulation of dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytoplasmic stress granule
- cytoplasm
- cell leading edge
- membrane
- cytoplasmic mRNA processing body
- intracellular non-membrane-bounded organelle
- cytosol
- synapse
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- RNA binding
- signaling adaptor activity
- mRNA binding