Ifnar2 Gene Summary [Mouse]
Enables type I interferon receptor activity. Acts upstream of or within immature T cell proliferation in thymus and regulation of transcription by RNA polymerase II. Located in extracellular space. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; liver; and nervous system. Human ortholog(s) of this gene implicated in hepatitis B and immunodeficiency 45. Orthologous to human IFNAR2 (interferon alpha and beta receptor subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ifnar2 |
| Official Name | interferon (alpha and beta) receptor 2 [Source:MGI Symbol;Acc:MGI:1098243] |
| Ensembl ID | ENSMUSG00000022971 |
| Bio databases IDs | |
| Aliases | interferon (alpha and beta) receptor 2 |
| Synonyms | beta subunit of type I IFNR, IFNABR, IFNalphabetaR, IFN-alpha-REC, IFNARB, IFN-R, IFN-R-2, IFN-α-REC, IFNαβR, IMD45, interferon (alpha and beta) receptor 2, interferon alpha and beta receptor subunit 2, interferon (α and β) receptor 2, interferon α and β receptor subunit 2, Type II IFNR, β subunit of type I IFNR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ifnar2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein kinase binding
- cytokine binding
- Interferon-alpha/beta receptor, fibronectin type III
- protein binding
- JAK pathway signal transduction adaptor
- Box I domain
- interferon-alpha/beta binding
- cytoplasmic domain
- transmembrane domain
- intracellular domain
- interferon-alpha/beta receptor
- Tissue factor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Ifnar2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- mycosis fungoides
- Sézary syndrome
- fibrosis
- rheumatoid arthritis
- COVID-19
- demyelination
- septic shock
- acute respiratory distress syndrome
- cancer
role in cell
- proliferation
- expression in
- production in
- apoptosis
- activation in
- growth
- replication in
- activity
- response
- signaling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ifnar2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to virus
- regulation of JAK-STAT cascade
- cell surface receptor signaling pathway
- response to virus
- response to interferon-alpha
- response to interferon-beta
- JAK-STAT cascade
- cellular response to interferon-beta
- type I interferon-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- JAK pathway signal transduction adaptor activity
- type I interferon receptor activity
- cytokine binding
- interleukin-22 receptor activity