Efna3 Gene Summary [Mouse]
Enables ephrin receptor binding activity. Involved in ephrin receptor signaling pathway. Predicted to be located in side of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human EFNA3 (ephrin A3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Efna3 |
| Official Name | ephrin A3 [Source:MGI Symbol;Acc:MGI:106644] |
| Ensembl ID | ENSMUSG00000028039 |
| Bio databases IDs | |
| Aliases | ephrin A3 |
| Synonyms | AW494418, EFL-2, Ehk1-L, EHK1 ligand, EPHRIN A3, Epl3, EPLG3, LERK-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Efna3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- transmembrane-ephrin receptor
- Ephrin
- Cupredoxin superfamily
- ephrin receptor binding
- protein binding
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Efna3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- nonalcoholic fatty liver disease
- papillary thyroid carcinoma
- papillary thyroid cancer
role in cell
- expression in
- phosphorylation in
- survival
- induction in
- migration
- invasion by
- sphere formation
- motility
- number
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Efna3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- ephrin receptor signaling pathway
- cell-cell signaling
- axon guidance
- regulation of neuron differentiation
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ephrin receptor binding
- transmembrane-ephrin receptor activity