Prrg4 Gene Summary [Mouse]
Predicted to enable WW domain binding activity and serine-type endopeptidase activity. Predicted to be involved in blood coagulation. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment membrane and extracellular region. Predicted to be active in extracellular space and plasma membrane. Orthologous to human PRRG4 (proline rich and Gla domain 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prrg4 |
| Official Name | proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) [Source:MGI Symbol;Acc:MGI:2442211] |
| Ensembl ID | ENSMUSG00000027171 |
| Bio databases IDs | |
| Aliases | proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) |
| Synonyms | 9930111I18Rik, LOC100506702, PRGP4, proline rich and Gla domain 4, proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane), RGD1560542, TMG4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prrg4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WW domain binding
- protein binding
- Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- mammary neoplasm
- metastasis
- breast carcinoma
- inguinal hernia
role in cell
- migration
- activation in
- invasion by
- binding in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prrg4 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- plasma membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- WW domain binding