Tspan18 Gene Summary [Mouse]
Predicted to enable transmembrane transporter binding activity. Acts upstream of or within several processes, including calcium-ion regulated exocytosis; hemostasis; and inflammatory response. Predicted to be located in cell periphery. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human TSPAN18 (tetraspanin 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tspan18 |
| Official Name | tetraspanin 18 [Source:MGI Symbol;Acc:MGI:1917186] |
| Ensembl ID | ENSMUSG00000027217 |
| Bio databases IDs | |
| Aliases | tetraspanin 18 |
| Synonyms | 2610042G18RIK, 6720430O15, Neuronal Tetraspanin, RGD1560411, tetraspanin 18, TSPAN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tspan18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tetraspanin_LEL
- ion channel binding
- protein binding
- Tetraspanin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- metastasis
- obstructive sleep apnea
- open-angle glaucoma
- organismal death
- schizophrenia
regulates
- Ca2+
- STIM1
role in cell
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cell periphery
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tspan18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- calcium ion-dependent exocytosis
- establishment of localization in cell
- hemostasis
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding