Duoxa2 Gene Summary [Mouse]
Predicted to enable enzyme binding activity. Acts upstream of or within hydrogen peroxide metabolic process; regulation of inflammatory response; and regulation of thyroid hormone generation. Predicted to be located in several cellular components, including apical part of cell; cell leading edge; and endoplasmic reticulum. Predicted to be active in membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; liver; lung; and small intestine. Human ortholog(s) of this gene implicated in thyroid dyshormonogenesis 5. Orthologous to human DUOXA2 (dual oxidase maturation factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Duoxa2 |
| Official Name | dual oxidase maturation factor 2 [Source:MGI Symbol;Acc:MGI:1914061] |
| Ensembl ID | ENSMUSG00000027225 |
| Bio databases IDs | |
| Aliases | dual oxidase maturation factor 2 |
| Synonyms | 9030623N16Rik, dual oxidase maturation factor 2, Nip2, RGD1560628, SIMNIPHOM, TDH5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Duoxa2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual oxidase maturation factor
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thyroid dyshormonogenesis 5
- hereditary disorder
- congenital hypothyroidism
- dextran sodium sulfate-induced colitis
- epithelial thyroid cancer
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- iodide organification defect
phenotypes
- abnormal auditory brainstem response
- abnormal bone structure
- abnormal clavicle morphology
- abnormal cranium morphology
- abnormal eyelid morphology
- abnormal femur morphology
- abnormal hair growth
- abnormal head morphology
- abnormal humerus morphology
- abnormal iris morphology
- abnormal joint morphology
- abnormal radius morphology
- abnormal snout morphology
- abnormal thoracic cage shape
- abnormal tibia morphology
- abnormal ulna morphology
- abnormal vertebrae morphology
- abnormal vertebral arch morphology
- abnormal zygomatic bone morphology
- absent pinna reflex
- decreased B cell number
- decreased B-2 B cell number
- decreased CD11b-high dendritic cell number
- decreased CD8-positive alpha-beta T cell number
- decreased KLRG1-positive NK cell number
- decreased Ly6C low monocyte number
- decreased NK cell number
- decreased body length
- decreased bone mineral content
- decreased bone mineral density
- decreased circulating amylase level
- decreased circulating glucose level
- decreased circulating thyroxine level
- decreased effector memory T-helper cell number
- decreased erythrocyte cell number
- decreased follicular B cell number
- decreased grip strength
- decreased heart weight
- decreased hematocrit
- decreased hemoglobin content
- decreased immature B cell number
- decreased lean body mass
- decreased leukocyte cell number
- decreased mature B cell number
- decreased mean platelet volume
- decreased memory CD4-positive CD25-positive alpha-beta regulatory T cell number
- decreased memory-marker gamma-delta T cell number
- decreased red blood cell distribution width
- decreased total body fat amount
- decreased transitional stage T1 B cell number
- increased CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased CD4-positive alpha beta T cell number
- increased CD8-positive alpha-beta T cell number
- increased CD8-positive naive alpha-beta T cell number
- increased T cell number
- increased T-helper cell number
- increased alpha-beta T cell number
- increased blood urea nitrogen level
- increased circulating HDL cholesterol level
- increased circulating LDL cholesterol level
- increased circulating aspartate transaminase level
- increased circulating calcium level
- increased circulating cholesterol level
- increased circulating creatinine level
- increased circulating fructosamine level
- increased circulating iron level
- increased circulating serum albumin level
- increased circulating sodium level
- increased circulating total protein level
- increased effector memory CD8-positive alpha-beta T cell number
- increased lean body mass
- increased mean corpuscular hemoglobin
- increased mean corpuscular hemoglobin concentration
- increased neutrophil cell number
- increased plasmacytoid dendritic cell number
- increased total body fat amount
- thrombocytopenia
- abnormal adipose tissue amount
- abnormal body length
- abnormal bone mineral density
- abnormal bone mineralization
- abnormal circulating HDL cholesterol level
- abnormal circulating LDL cholesterol level
- abnormal circulating calcium level
- abnormal circulating cholesterol level
- abnormal circulating creatinine level
- abnormal circulating fructosamine level
- abnormal circulating glucose level
- abnormal circulating sodium level
- abnormal circulating thyroxine level
- abnormal circulating total protein level
- abnormal erythrocyte cell number
- abnormal grip strength
- abnormal heart weight
- abnormal hematocrit
- abnormal hemoglobin content
- abnormal lean body mass
- abnormal leukocyte cell number
- abnormal mean corpuscular hemoglobin
- abnormal platelet volume
- abnormal red blood cell distribution width
- no abnormal phenotype detected
role in cell
- generation in
- processing in
- folding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- apical compartment
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Duoxa2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of hydrogen peroxide biosynthetic process
- regulation of thyroid hormone generation
- protein transport
- protein localization
- regulation of inflammatory response
- protein maturation
- hydrogen peroxide metabolic process
- positive regulation of cell motility
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- apical part of cell
- cell leading edge
- membrane
- cytosol
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme binding