Asic1 Gene Summary [Mouse]
Enables monoatomic cation channel activity; monoatomic ion-gated channel activity; and pH-gated monoatomic ion channel activity. Involved in regulation of postsynapse assembly. Acts upstream of or within several processes, including behavioral fear response; learning or memory; and response to amphetamine. Located in synapse. Is active in glutamatergic synapse and plasma membrane. Is expressed in several structures, including brain. Orthologous to human ASIC1 (acid sensing ion channel subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Asic1 |
| Official Name | acid-sensing (proton-gated) ion channel 1 [Source:MGI Symbol;Acc:MGI:1194915] |
| Ensembl ID | ENSMUSG00000023017 |
| Bio databases IDs | |
| Aliases | acid-sensing (proton-gated) ion channel 1 |
| Synonyms | ACCN2, acid-sensing ion channel 1, acid sensing ion channel subunit 1, ASIC, ASIC1a, ASIC1b, B530003N02Rik, BNaC2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Asic1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- channel/pore class transporter
- amiloride-sensitive sodium channel
- sodium channel transporter
- ligand-gated ion channel
- inorganic uptake permease
- protein binding
- ion channel
- cation channel
- degenerin
Pathways
Biological processes and signaling networks where the Asic1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- schizophrenia
- cardiovascular disorder
- disorder of coronary artery
- chronic kidney disease
- acute pain
- ankle sprain
- traumatic brain injury
- knee osteoarthritis
regulates
- Ca2+
- AKT
- reactive oxygen species
- ERK
- inorganic cation
- GRIA1
- neurotransmitter
- ion
- mir-350 (includes others)
- 26S proteasome
role in cell
- expression in
- proliferation
- phosphorylation in
- apoptosis
- activation
- depolarization
- damage
- migration by
- production in
- synaptic transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- Golgi Apparatus
- Mitochondria
- synaptic membrane
- dendritic spines
- nerve ending
- synapse
- perikaryon
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Asic1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sour taste
- negative regulation of neurotransmitter secretion
- associative learning
- memory
- neurotransmitter secretion
- behavioral fear response
- sodium ion transport
- regulation of membrane potential
- response to amphetamine
- calcium ion transmembrane transport
- sodium ion transmembrane transport
- cellular response to pH
- response to acidity
- protein homotrimerization
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- ion gated channel activity
- protein binding
- ligand-gated sodium channel activity