Mogs Gene Summary [Mouse]
Predicted to enable Glc3Man9GlcNAc2 oligosaccharide glucosidase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIb. Orthologous to human MOGS (mannosyl-oligosaccharide glucosidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mogs |
| Official Name | mannosyl-oligosaccharide glucosidase [Source:MGI Symbol;Acc:MGI:1929872] |
| Ensembl ID | ENSMUSG00000030036 |
| Bio databases IDs | |
| Aliases | mannosyl-oligosaccharide glucosidase |
| Synonyms | 1810017N02Rik, AI181835, CDG2B, CWH41, DER7, GCS1, GLUCOSIDASE I, LOC103692171, mannosyl-oligosaccharide glucosidase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mogs often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- trehalase
- mannosyl-oligosaccharide glucosidase
- glucosidase
- enzyme
- Glycosyl hydrolase family 63 C-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital disorder of glycosylation type 2b
- insulin-dependent diabetes mellitus
regulates
- S
- Core
- Phaseolus vulgaris leukoagglutinin
- PROM1
role in cell
- expression in
- binding
- growth
- lipotoxicity in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mogs gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral protein processing
- protein N-linked glycosylation
- oligosaccharide metabolic process
- protein folding
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- glucosidase activity
- mannosyl-oligosaccharide glucosidase activity