Vps39 Gene Summary [Mouse]
Predicted to be involved in endocytic recycling; lysosomal transport; and vesicle fusion. Part of AP-3 adaptor complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human VPS39 (VPS39 subunit of HOPS complex). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vps39 |
| Official Name | VPS39 HOPS complex subunit [Source:MGI Symbol;Acc:MGI:2443189] |
| Ensembl ID | ENSMUSG00000027291 |
| Bio databases IDs | |
| Aliases | VPS39 HOPS complex subunit |
| Synonyms | A230065P22Rik, FLJ21681, hVam6p, mVam6, TLP, VAM6, Vam6P, VPS39 HOPS complex subunit, VPS39 subunit of HOPS complex |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vps39 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CNH domain
- Vacuolar sorting protein 39 domain 2
- Region in Clathrin and VPS
- protein binding
- Vacuolar sorting protein 39 domain 1
- transporter
Pathways
Biological processes and signaling networks where the Vps39 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- infection by feline infectious peritonitis virus
- infection by murine hepatitis virus
role in cell
- activation in
- phosphorylation in
- growth
- synthesis in
- clustering
- fragmentation
- fusion
- autophagy by
- fragmentation in
- clustering in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- vesicles
- lysosome
- cytosol
- lysosome membrane
- endosomal membrane
- late endosomes
- cortical vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vps39 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of SNARE complex assembly
- autophagy
- endosome to lysosome transport
- endosomal vesicle fusion
- intracellular protein transport
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- cytoplasm
- membrane
- late endosome
- AP-3 adaptor complex
- endosome membrane
- lysosomal membrane
- HOPS complex
Molecular Function
What the gene product does at the molecular level
- protein binding