Ptpra Gene Summary [Mouse]
Enables protein tyrosine phosphatase activity. Involved in integrin-mediated signaling pathway; modulation of chemical synaptic transmission; and regulation of focal adhesion assembly. Acts upstream of or within insulin receptor signaling pathway and protein phosphorylation. Located in focal adhesion and membrane. Is active in Schaffer collateral - CA1 synapse and synaptic membrane. Is expressed in several structures, including adrenal gland; central nervous system; extraembryonic component; future brain; and genitourinary system. Orthologous to human PTPRA (protein tyrosine phosphatase receptor type A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptpra |
| Official Name | protein tyrosine phosphatase, receptor type, A [Source:MGI Symbol;Acc:MGI:97808] |
| Ensembl ID | ENSMUSG00000027303 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, receptor type, A |
| Synonyms | HEPTP, HLPR, HPTPA, HPTPalpha, Leukocyte common antigen-related peptide (protein tyrosine phosphate), LOC360370, LRP, protein tyrosine phosphatase receptor type A, protein tyrosine phosphatase, receptor type, A, PTPA, PTP[a], Ptpalpha, PTPRL2, PTP-α, RPTPA, R-PTP-alpha, R-PTP-α, Rptra, Rptralpha |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptpra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein-tyrosine-phoshatase
- catalytic domain
- Protein tyrosine phosphatase, catalytic domain
- PTP_DSP_cys
- protein binding
- phosphatase domain
- membrane-proximal phosphatase domain
- Protein tyrosine phosphatase, catalytic domain motif
- Grb2 binding domain
- phosphorylation site
- PTPase domain
- membrane distal domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- binding protein
- cytoplasmic domain
- transmembrane receptor protein tyrosine phosphatase
- transmembrane domain
- phosphatase
- membrane-proximal domain
Pathways
Biological processes and signaling networks where the Ptpra gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- HIV infection
- metastasis
- organismal death
- mammary neoplasm
- colon neoplasm
- colorectal neoplasia
- liver neoplasia
- dystonia type 30
role in cell
- expression in
- accumulation in
- activation in
- formation
- phosphorylation in
- proliferation
- quantity
- migration
- growth
- cell spreading
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- Cytoplasm
- membrane surface
- cellular membrane
- focal adhesions
- endosomes
- Endoplasmic Reticulum
- synaptic membrane
- synapse
- zonula adherens
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptpra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of focal adhesion assembly
- integrin-mediated signaling pathway
- insulin receptor signaling pathway
- protein dephosphorylation
- regulation of synaptic transmission
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- membrane
- receptor complex
- synaptic membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tyrosine phosphatase activity
- transmembrane receptor protein tyrosine phosphatase activity