Ptprn2 Gene Summary [Mouse]
Predicted to enable histone H2AXY142 phosphatase activity; non-membrane spanning protein tyrosine phosphatase activity; and protein tyrosine phosphatase activity, metal-dependent. Involved in insulin secretion involved in cellular response to glucose stimulus and neurotransmitter secretion. Located in secretory granule membrane and synaptic vesicle membrane. Is expressed in several structures, including foregut-midgut junction; midgut endoderm; and nervous system. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Orthologous to human PTPRN2 (protein tyrosine phosphatase receptor type N2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ptprn2 |
| Official Name | protein tyrosine phosphatase, receptor type, N polypeptide 2 [Source:MGI Symbol;Acc:MGI:107418] |
| Ensembl ID | ENSMUSG00000056553 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, receptor type, N polypeptide 2 |
| Synonyms | 4930425H11RIK, IA-2, IA-2beta, Ia2 β, IAR, ICAAR, KIAA0387, mKIAA0387, phogrin, PHOL, protein tyrosine phosphatase receptor type N2, protein tyrosine phosphatase, receptor type N2, protein tyrosine phosphatase receptor type N polypeptide 2, PTPNE6, PTP-NP, PTPRN2 isoform 1, PTPRP, R-PTP-N2, TRANSMEMBRANE-type protein TYROSINE PHOSPHATASE II |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptprn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- cytoplasmic domain
- catalytic domain
- transmembrane receptor protein tyrosine phosphatase
- phosphatase
- Protein tyrosine phosphatase, catalytic domain
- PTP_DSP_cys
- protein binding
- Protein-tyrosine phosphatase receptor IA-2
- Protein tyrosine phosphatase, catalytic domain motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- seizures
- COVID-19
- schizophrenia
- psoriasis
- colorectal cancer
- coronary artery disease
- prostate cancer
- idiopathic scoliosis
- osteoarthritis
role in cell
- survival
- expression in
- quantity
- morphology
- dephosphorylation in
- mitogenesis in
- oxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- presynaptic regions
- perinuclear region
- cellular membrane
- secretory granule membrane
- granules
- cytosol
- vesicle membrane
- endoplasmic reticulum lumen
- apical membrane
- synaptic vesicles
- dense-core vesicles
- cytoplasmic vesicles
- storage granules
- secretory granules
- membrane processes
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptprn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of secretion
- insulin secretion involved in cellular response to glucose stimulus
- lipid metabolic process
- protein dephosphorylation
- neurotransmitter secretion
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- secretory granule
- receptor complex
- synapse
- synaptic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane receptor protein tyrosine phosphatase activity