Fancg Gene Summary [Mouse]
Acts upstream of or within several processes, including DNA damage response; ovarian follicle development; and spermatid development. Predicted to be located in several cellular components, including chromatin; mitochondrion; and nucleolus. Predicted to be part of Fanconi anaemia nuclear complex. Is expressed in gut dorsal mesentery and reproductive system. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group G; and pancreatic cancer. Orthologous to human FANCG (FA complementation group G). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fancg |
| Official Name | Fanconi anemia, complementation group G [Source:MGI Symbol;Acc:MGI:1926471] |
| Ensembl ID | ENSMUSG00000028453 |
| Bio databases IDs | |
| Aliases | Fanconi anemia, complementation group G |
| Synonyms | AU041407, FA complementation group G, FAG, Fanconi anaemia, complementation group G, Fanconi anemia, complementation group G, LOC684204, XRCC9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fancg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- damaged DNA binding
- serine phosphorylation site
- protein binding
- tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the Fancg gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pancreatic cancer
- epithelial cancer
- pancreaticobiliary cancer
- epithelial neoplasia
- cancer
- digestive system cancer
- abdominal cancer
- breast cancer
- hyperplasia
- Fanconi anemia group G
role in cell
- expression in
- molecular cleavage in
- cell death
- cell viability
- survival
- replication in
- cell cycle progression
- killing
- colony survival
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- Cytoplasm
- Plasma Membrane
- Mitochondria
- cytosol
- nuclear foci
- nucleoplasm
- nucleoli
- nuclear speckles
- nuclear matrix
- chromatin foci
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fancg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- spermatid development
- response to radiation
- response to DNA damage stimulus
- mitochondrion organization
- ovarian follicle development
Cellular Component
Where in the cell the gene product is active
- Fanconi anaemia nuclear complex
- mitochondrion
- cytosol
- nucleolus
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- damaged DNA binding