Nkx2-2 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including endocrine pancreas development; neurogenesis; and positive regulation of cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; neural ectoderm; and sensory organ. Orthologous to human NKX2-2 (NK2 homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nkx2-2 |
| Official Name | NK2 homeobox 2 [Source:MGI Symbol;Acc:MGI:97347] |
| Ensembl ID | ENSMUSG00000027434 |
| Bio databases IDs | |
| Aliases | NK2 homeobox 2 |
| Synonyms | NK2 homeobox 2, NKX2.2, NKX2B, tinman |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nkx2-2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- NK2-specific domain
- nucleic acid binding
- double-stranded DNA binding
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
- TN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma cancer
- glioma cancer
- cancer
- glioma formation
- central nervous system cancer
- hypoplasia
- hyperglycemia
- growth failure
role in cell
- formation
- expression in
- quantity
- number
- differentiation
- development
- specification
- cell survival
- transactivation in
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular space
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nkx2-2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte development
- ventral spinal cord interneuron fate determination
- response to progesterone stimulus
- negative regulation of neuron differentiation
- positive regulation of neuron differentiation
- positive regulation of transcription from RNA polymerase II promoter
- spinal cord oligodendrocyte cell fate specification
- optic nerve development
- positive regulation of oligodendrocyte differentiation
- response to glucose stimulus
- pancreatic A cell fate commitment
- type B pancreatic cell fate commitment
- neuron fate specification
- pancreatic PP cell fate commitment
- digestive tract development
- neuroendocrine cell differentiation
- astrocyte differentiation
- spinal cord motor neuron differentiation
- smoothened signaling pathway
- brain development
- type B pancreatic cell development
- regulation of transcription from RNA polymerase II promoter
- positive regulation of epithelial cell differentiation
- positive regulation of gene expression
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity