Mlph Gene Summary [Mouse]
Enables cytoskeletal protein binding activity; molecular adaptor activity; and small GTPase binding activity. Acts upstream of or within melanocyte differentiation; melanosome localization; and protein targeting. Located in cytoskeleton and melanosome. Part of unconventional myosin complex. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver; and musculature. Human ortholog(s) of this gene implicated in Griscelli syndrome type 3. Orthologous to human MLPH (melanophilin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mlph |
| Official Name | melanophilin [Source:MGI Symbol;Acc:MGI:2176380] |
| Ensembl ID | ENSMUSG00000026303 |
| Bio databases IDs | |
| Aliases | melanophilin |
| Synonyms | 2210418F23Rik, 5031433I09Rik, D1Wsu84e, EXOPHILIN 3, l(1)-3Rk, l1Rk3, ln, MELANOPHILIN, SLAC2-A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mlph often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- myosin va binding domain
- exon F-binding domain
- protein binding activity, bridging
- enzyme binding
- coiled-coil domain
- protein binding
- Slp homology domain
- FYVE domain like superfamily
- PEST domain
- myosin binding
- actin-binding domain
- actin binding
- PHD finger superfamily
- microtubule plus-end binding
- zinc finger domain
- Rab27 binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- lung cancer
- prostatic carcinoma
- prostate cancer
- head and neck neoplasia
- metastatic colorectal cancer
- Griscelli syndrome
- systemic juvenile idiopathic arthritis
- Griscelli syndrome type 3
- COVID-19
role in cell
- differentiation
- aggregation
- signaling in
- accumulation
- radioresistance
- localization
- transport
- distribution
- actin-based transport in
- clustering
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- dendrite tip
- cortical actin cytoskeleton
- cell periphery
- perinuclear region
- actin cytoskeleton
- vesicles
- microtubules
- microtubule organizing centers
- cytosol
- melanosomes
- plus end of microtubule
- actin stress fibers
- dendrites
- melanosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mlph gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular protein transport
- melanosome transport
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- metal ion binding
- myosin binding
- small GTPase binding
- protein binding, bridging