Sycp1 Gene Summary [Mouse]
Predicted to enable double-stranded DNA binding activity. Involved in reciprocal meiotic recombination and synaptonemal complex assembly. Acts upstream of or within meiosis I cell cycle process; regulation of protein localization; and sperm DNA condensation. Located in autosome; male germ cell nucleus; and synaptonemal complex. Is expressed in several structures, including brain; heart; and reproductive system. Orthologous to human SYCP1 (synaptonemal complex protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sycp1 |
| Official Name | synaptonemal complex protein 1 [Source:MGI Symbol;Acc:MGI:105931] |
| Ensembl ID | ENSMUSG00000027855 |
| Bio databases IDs | |
| Aliases | synaptonemal complex protein 1 |
| Synonyms | CT8, HOM-TES-14, SCP-1, synaptonemal complex protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sycp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromosome segregation protein SMC, common bacterial type
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- double-stranded DNA binding
- Synaptonemal complex protein 1 (SCP-1)
- helix-rich Mycoplasma protein
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- autosome
- centromeric region
- chromosome
- nucleoplasm
- spindle fibers
- synaptonemal complexes
- telomeres
- chromosomal axial elements
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sycp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- chiasma assembly
- protein homotetramerization
- reciprocal meiotic recombination
- regulation of protein localization
- spermatogenesis
- synaptonemal complex assembly
- sperm chromatin condensation
- meiotic DNA repair synthesis
- lateral element assembly
- synapsis
Cellular Component
Where in the cell the gene product is active
- autosome
- transverse filament
- central element
- chromosome
- chromosome, centromeric region
- synaptonemal complex
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- double-stranded DNA binding