Prdm9 Gene Summary [Mouse]
Enables DNA binding activity; protein homodimerization activity; and protein-lysine N-methyltransferase activity. Involved in several processes, including male gamete generation; meiosis I; and positive regulation of fertilization. Acts upstream of or within positive regulation of meiotic nuclear division; positive regulation of transcription by RNA polymerase II; and spermatogenesis. Located in chromatin and nucleus. Is expressed in several structures, including adrenal gland; gonad; nervous system; notochord; and sensory organ. Orthologous to several human genes including PRDM9 (PR/SET domain 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prdm9 |
| Official Name | PR domain containing 9 [Source:MGI Symbol;Acc:MGI:2384854] |
| Ensembl ID | ENSMUSG00000051977 |
| Bio databases IDs | |
| Aliases | PR domain containing 9 |
| Synonyms | BC012016, Dsbc1, G1-419-29, KMT8B, MEISETZ, MSBP3, PFM6, Prdm7, PRDM9-B, PR domain containing 9, PR/SET domain 9, Rcr1, repro7, ZNF899 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prdm9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- nucleic acid binding
- enzyme
- SSXRD motif
- protein binding
- KRAB (Kruppel-associated box) domain -A box
- sequence-specific DNA binding
- DNA binding
- krueppel associated box
- histone lysine N-methyltransferase activity (H3-K4 specific)
- double-stranded DNA binding
- histone lysine N-methyltransferase activity (H3-K36 specific)
- Zinc-finger double domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- protein homodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prdm9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- female gamete generation
- male gamete generation
- chromatin remodeling
- positive regulation of reciprocal meiotic recombination
- negative regulation of apoptotic process
- regulation of gene expression
- regulation of transcription, DNA-dependent
- meiotic gene conversion
- synapsis
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone methyltransferase activity (H3-K4 specific)
- zinc ion binding
- protein homodimerization activity
- transcription regulatory region sequence-specific DNA binding
- histone methyltransferase activity (H3-K36 specific)
- recombination hotspot binding