SYCP1 Gene Summary [Human]
Enables double-stranded DNA binding activity. Involved in protein homotetramerization. Predicted to be located in synaptonemal complex. Predicted to be active in central element; male germ cell nucleus; and transverse filament. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SYCP1 |
| Official Name | synaptonemal complex protein 1 [Source:HGNC Symbol;Acc:HGNC:11487] |
| Ensembl ID | ENSG00000198765 |
| Bio databases IDs | |
| Aliases | synaptonemal complex protein 1, cancer/testis antigen 8 |
| Synonyms | CT8, HOM-TES-14, SCP-1, synaptonemal complex protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SYCP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromosome segregation protein SMC, common bacterial type
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- double-stranded DNA binding
- Synaptonemal complex protein 1 (SCP-1)
- helix-rich Mycoplasma protein
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- autosome
- centromeric region
- chromosome
- nucleoplasm
- spindle fibers
- synaptonemal complexes
- telomeres
- chromosomal axial elements
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SYCP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- chiasma assembly
- protein homotetramerization
- reciprocal meiotic recombination
- regulation of protein localization
- spermatogenesis
- synaptonemal complex assembly
- sperm chromatin condensation
- meiotic DNA repair synthesis
- lateral element assembly
- synapsis
Cellular Component
Where in the cell the gene product is active
- autosome
- transverse filament
- central element
- chromosome
- chromosome, centromeric region
- synaptonemal complex
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- double-stranded DNA binding