Ddx20 Gene Summary [Mouse]
Enables histone deacetylase binding activity and protein-macromolecule adaptor activity. Involved in positive regulation of apoptotic process. Acts upstream of or within negative regulation of transcription by RNA polymerase II; oogenesis; and regulation of steroid biosynthetic process. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including brain; branchial arch; genitourinary system; hemolymphoid system; and liver. Orthologous to human DDX20 (DEAD-box helicase 20). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddx20 |
| Official Name | DEAD box helicase 20 [Source:MGI Symbol;Acc:MGI:1858415] |
| Ensembl ID | ENSMUSG00000027905 |
| Bio databases IDs | |
| Aliases | DEAD box helicase 20 |
| Synonyms | Component of gems 3, DEAD-box helicase 20, DEAD-box protein 20, DP103, GEMIN3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddx20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- DEAD/DEAH box helicase
- protein binding activity, bridging
- helicase superfamily c-terminal domain
- transcription factor binding
- histone deacetylase binding
- protein domain specific binding
- protein binding
- Helicase conserved C-terminal domain
- RNA helicase
- transcription repression domain
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- venous thromboembolism
- liver cancer
- lung cancer
role in cell
- apoptosis
- proliferation
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- polyribosome fractions
- cytoskeleton
- Cytoplasm
- cytosol
- gems
- nucleoplasm
- nuclear bodies
- Cajal bodies
- perikaryon
- axons
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddx20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- oogenesis
- negative regulation of cell proliferation
- positive regulation of apoptotic process
- RNA processing
- regulation of steroid biosynthetic process
- assembly of spliceosomal tri-snRNP
- spliceosomal snRNP assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoskeleton
- cytoplasm
- membrane
- SMN-Sm protein complex
- cytosol
- SMN complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA binding
- protein domain specific binding
- protein binding
- RNA helicase activity
- histone deacetylase binding
- mRNA binding
- protein binding, bridging