Stag2 Gene Summary [Mouse]
Enables chromatin binding activity. Acts upstream of or within stem cell population maintenance. Located in chromatin. Is expressed in several structures, including genitourinary system; integumental system; limb; liver; and nervous system. Human ortholog(s) of this gene implicated in Holoprosencephaly 13, X-linked and Mullegama-Klein-Martinez syndrome. Orthologous to human STAG2 (STAG2 cohesin complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stag2 |
| Official Name | stromal antigen 2 [Source:MGI Symbol;Acc:MGI:1098583] |
| Ensembl ID | ENSMUSG00000025862 |
| Bio databases IDs | |
| Aliases | stromal antigen 2 |
| Synonyms | 9230105L23Rik, B230112I07Rik, bA517O1.1, HPE13, MKMS, NEDXCF, RGD1562042, SA-2, SAP2, SCC3B, STAG2 cohesin complex component, Stromal antigen 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stag2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromatin binding
- protein binding
- STAG domain
Pathways
Biological processes and signaling networks where the Stag2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- chronic myeloid leukemia
- idiopathic hypereosinophilic syndrome
- myeloid neoplasia
- serous ovarian adenocarcinoma
- serous ovarian cancer
- hereditary disorder
- breast adenocarcinoma
- X-linked neurodevelopmental disorder with craniofacial abnormalities
- secondary acute myeloid leukemia
role in cell
- expression in
- growth
- phosphorylation in
- transcription in
- differentiation
- cohesion
- assembly
- cohesion in
- segregation in
- segregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- fibrillar center
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
- nucleoli
- spindle pole
- nuclear matrix
- centromeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stag2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- sister chromatid cohesion
- meiotic cell cycle
- establishment of mitotic sister chromatid cohesion
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- cohesin complex
- chromosome
- nucleolus
- chromosome, centromeric region
- chromatin
- fibrillar center
- nucleoplasm
- nucleus
- membrane
- cytosol
- nuclear matrix
- mitotic cohesin complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding