Plrg1 Gene Summary [Mouse]
Acts upstream of or within positive regulation of G1/S transition of mitotic cell cycle and protein localization to nucleus. Predicted to be located in fibrillar center; nuclear membrane; and nuclear speck. Predicted to be part of DNA replication factor A complex; Prp19 complex; and U2-type catalytic step 2 spliceosome. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human PLRG1 (pleiotropic regulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plrg1 |
| Official Name | pleiotropic regulator 1 [Source:MGI Symbol;Acc:MGI:1858197] |
| Ensembl ID | ENSMUSG00000027998 |
| Bio databases IDs | |
| Aliases | pleiotropic regulator 1 |
| Synonyms | AA958940, Cwc1, pleiotropic regulator 1, PRL1, PRP46, PRPF46, TANGO4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plrg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- fibrillar center
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
- nuclear envelope
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plrg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of G1/S transition of mitotic cell cycle
- protein localization to nucleus
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- catalytic step 2 spliceosome
- nuclear speck
- U2-type catalytic step 2 spliceosome
- spliceosomal complex
- DNA replication factor A complex
- Prp19 complex
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding