Srrm1 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Predicted to be involved in regulation of mRNA splicing, via spliceosome. Predicted to act upstream of or within mRNA splicing, via spliceosome. Part of spliceosomal complex. Is expressed in central nervous system; genitourinary system; pancreas epithelium; and sensory organ. Orthologous to human SRRM1 (serine and arginine repetitive matrix 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Srrm1 |
| Official Name | serine/arginine repetitive matrix 1 [Source:MGI Symbol;Acc:MGI:1858303] |
| Ensembl ID | ENSMUSG00000028809 |
| Bio databases IDs | |
| Aliases | serine/arginine repetitive matrix 1 |
| Synonyms | B1C8, POP101, serine and arginine repetitive matrix 1, serine/arginine repetitive matrix 1, serine/arginine repetitive matrix protein 1, SRM160 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Srrm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PWI, domain in splicing factors
- PWI domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- preeclampsia
- cleft lip
- alopecia
role in cell
- splicing by
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- spindle apparatus
- catalytic step 2 spliceosome
- centriole
- cytosol
- spliceosomes
- nucleoplasm
- nuclear speckles
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Srrm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing, via transesterification reactions
- RNA splicing
- regulation of nuclear mRNA splicing, via spliceosome
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- nuclear speck
- spliceosomal complex
- nuclear matrix
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding