Pde7a Gene Summary [Mouse]
Enables 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human PDE7A (phosphodiesterase 7A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pde7a |
| Official Name | phosphodiesterase 7A [Source:MGI Symbol;Acc:MGI:1202402] |
| Ensembl ID | ENSMUSG00000069094 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 7A |
| Synonyms | FLJ33024, HCP1, PDE7, PDE7-1, Phosphodiesterase 7a |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pde7a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metal dependent phosphohydrolases with conserved 'HD' motif
- 3'5'-cyclic nucleotide phosphodiesterase
- cyclic-nucleotide phosphodiesterase
- cAMP-specific phosphodiesterase
- enzyme
- HDc
Pathways
Biological processes and signaling networks where the Pde7a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumor
- liver disease
- infection
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- chronic kidney disease
- pulmonary fibrosis
- estrogen receptor positive HER2 negative PIK3CA mutation positive breast cancer
- stroke
- pulmonary emphysema
regulates
- MTORC1
role in cell
- signaling in
- taselisib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pde7a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cAMP catabolic process
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- 3',5'-cyclic-GMP phosphodiesterase activity
- 3',5'-cyclic-AMP phosphodiesterase activity