Lrwd1 Gene Summary [Mouse]
Predicted to enable chromatin binding activity; methyl-CpG binding activity; and methylated histone binding activity. Predicted to be involved in chromatin organization and establishment of protein localization to chromatin. Predicted to be located in chromosomal region and nuclear lumen. Predicted to be part of nuclear origin of replication recognition complex. Is expressed in embryo. Orthologous to human LRWD1 (leucine rich repeats and WD repeat domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrwd1 |
| Official Name | leucine-rich repeats and WD repeat domain containing 1 [Source:MGI Symbol;Acc:MGI:1918985] |
| Ensembl ID | ENSMUSG00000029703 |
| Bio databases IDs | |
| Aliases | leucine-rich repeats and WD repeat domain containing 1 |
| Synonyms | 1200011O22Rik, CENP-33, leucine-rich repeats and WD repeat domain containing 1, ORCA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrwd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- histone binding
- protein binding activity, bridging
- Leucine rich repeat
- WD domain, G-beta repeat
- chromatin binding
- WD40
- protein binding
- Leucine Rich repeats (2 copies)
- leucine-rich repeat
- WD40 repeats
- methyl-CpG binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatic focus
- intracellular membrane-bounded organelle
- telomeric heterochromatin
- nuclear foci
- nucleoplasm
- nucleoli
- kinetochores
- centromeres
- telomeres
- centromeric heterochromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrwd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication initiation
- establishment of protein localization to chromatin
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- centrosome
- cytoplasm
- intracellular membrane-bounded organelle
- kinetochore
- nucleolus
- nuclear origin of replication recognition complex
- centromeric heterochromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- methylated histone residue binding
- chromatin binding
- methyl-CpG binding