Zwint Gene Summary [Mouse]
Involved in homologous chromosome orientation in meiotic metaphase I and regulation of meiosis I spindle assembly checkpoint. Located in kinetochore. Is expressed in several structures, including early conceptus; heart valve; nervous system; oocyte; and retina. Orthologous to human ZWINT (ZW10 interacting kinetochore protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zwint |
| Official Name | ZW10 interactor [Source:MGI Symbol;Acc:MGI:1289227] |
| Ensembl ID | ENSMUSG00000019923 |
| Bio databases IDs | |
| Aliases | ZW10 interactor |
| Synonyms | 2010007E07Rik, 2600001N01Rik, D10ERTD749E, HZwint-1, KNTC2AP, SIP30, Snap25 interacting protein 30, ZW10 interacting kinetochore protein, ZW10 interactor, ZWINT-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zwint often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- ZW10 interactor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- epithelial cancer
- androgenic alopecia
- lung adenocarcinoma
- lung adenocarcinoma formation
- castration refractory prostate carcinoma
- castration refractory prostate cancer
- colon cancer
- liver cancer
- hepatocellular carcinoma
role in cell
- segregation
- misalignment in
- mitosis
- spindle checkpoint
- misalignment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear bodies
- nuclear matrix
- kinetochores
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zwint gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- mitotic cell cycle spindle assembly checkpoint
- homologous chromosome orientation involved in meiotic metaphase I plate congression
- mitotic sister chromatid segregation
- establishment of localization in cell
Cellular Component
Where in the cell the gene product is active
- dendrite
- nuclear body
- cytoplasm
- cytosol
- kinetochore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding