Ptbp2 Gene Summary [Mouse]
Enables mRNA binding activity. Acts upstream of or within mRNA splice site recognition and regulation of neural precursor cell proliferation. Part of spliceosomal complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PTBP2 (polypyrimidine tract binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptbp2 |
| Official Name | polypyrimidine tract binding protein 2 [Source:MGI Symbol;Acc:MGI:1860489] |
| Ensembl ID | ENSMUSG00000028134 |
| Bio databases IDs | |
| Aliases | polypyrimidine tract binding protein 2 |
| Synonyms | brPTB, nPTB, polypyrimidine tract binding protein 2, PTB2, PTBLP, PTBLP-L, PTBLP-S |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RRM-like domain
- RNA recognition motif (RRM) superfamily
- hnRNP-L/PTB/hephaestus splicing factor family
- RNA recognition motif
- mRNA binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- progressive supranuclear palsy
- respiratory failure
- obesity
- neurodegeneration
- paralysis
role in cell
- formation in
- expression in
- proliferation
- formation
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- spliceosomes
- nucleoli
- growth cone
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptbp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of RNA splicing
- mRNA splice site selection
- regulation of neural precursor cell proliferation
- negative regulation of RNA splicing
Cellular Component
Where in the cell the gene product is active
- nucleus
- spliceosomal complex
Molecular Function
What the gene product does at the molecular level
- RNA binding
- mRNA binding