Dapp1 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in liver left lobe; liver right lobe; olfactory epithelium; and thymus primordium. Orthologous to human DAPP1 (dual adaptor of phosphotyrosine and 3-phosphoinositides 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dapp1 |
| Official Name | dual adaptor for phosphotyrosine and 3-phosphoinositides 1 [Source:MGI Symbol;Acc:MGI:1347063] |
| Ensembl ID | ENSMUSG00000028159 |
| Bio databases IDs | |
| Aliases | dual adaptor for phosphotyrosine and 3-phosphoinositides 1 |
| Synonyms | BAM32, dual adaptor for phosphotyrosine and 3-phosphoinositides 1, dual adaptor of phosphotyrosine and 3-phosphoinositides 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dapp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- phosphatidylinositol-3,4,5-triphosphate binding
- PI(3,4,5)P3-binding domain
- PH domain
- Src homology 2 (SH2) domain
- protein binding
- Pleckstrin homology-like domain
- phosphorylation site
Pathways
Biological processes and signaling networks where the Dapp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- ulcerative colitis
- diabetic nephropathy
role in cell
- proliferation
- activation
- number
- development
- polymerization
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dapp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- protein binding
- phospholipid binding
- phosphatidylinositol-3,4-bisphosphate binding