Gbp2 Gene Summary [Mouse]
Predicted to enable several functions, including cytoskeletal protein binding activity; guanyl ribonucleotide binding activity; and pyrophosphatase activity. Involved in several processes, including cellular response to interferon-beta; cytolysis in another organism; and positive regulation of defense response. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; defense response to other organism; and protein-containing complex assembly. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Is active in symbiont cell surface. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to several human genes including GBP2 (guanylate binding protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gbp2 |
| Official Name | guanylate binding protein 2 [Source:MGI Symbol;Acc:MGI:102772] |
| Ensembl ID | ENSMUSG00000028270 |
| Bio databases IDs | |
| Aliases | guanylate binding protein 2 |
| Synonyms | guanylate binding protein 2, Ifn-induced guanylate-binding protein 2 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- guanosine-diphosphatase
- GTPase regulator
- cytokine binding
- heat shock protein binding
- small monomeric GTPase
- GTPase
- spectrin binding
- enzyme binding
- enzyme
- identical protein binding
- lipopolysaccharide binding
- Guanylate-binding protein, C-terminal domain
- GTP binding
- endopeptidase inhibitor
- GTPase domain
- Guanylate-binding protein, N-terminal domain
- GDP binding
- actin binding
- protein homodimerization
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- dextran sodium sulfate-induced colitis
- infection by Toxoplasma gondii ME49
role in cell
- expression in
- transcription in
- binding in
- activation in
- response by
- cell spreading
- replication in
- response
- replication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- vesicle membrane
- Golgi membrane
- nucleoplasm
- cytoplasmic vesicles