Cse1l Gene Summary [Mouse]
Predicted to enable nuclear export signal receptor activity. Predicted to be involved in protein export from nucleus and protein import into nucleus. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nuclear envelope. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and skeletal musculature. Orthologous to human CSE1L (chromosome segregation 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Cse1l |
| Official Name | chromosome segregation 1-like (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1339951] |
| Ensembl ID | ENSMUSG00000002718 |
| Bio databases IDs | |
| Aliases | chromosome segregation 1-like (S. cerevisiae) |
| Synonyms | 2610100P18Rik, Capts, CAS, chromosome segregation 1 like, CSE1, Exportin-2, XPO2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cse1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cse1
- CAS/CSE protein, C-terminus
- protein binding
- zinc finger domain
- Importin-beta N-terminal domain
- basic domain
- nuclear export signal receptor
- transporter
Pathways
Biological processes and signaling networks where the Cse1l gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- cancer
- epithelial cancer
- hepatocellular carcinoma
- Parkinson disease
- breast cancer
- metastasis
- major depression
- endometrial carcinoma
- epithelial endometrial cancer
role in cell
- expression in
- apoptosis
- cell death
- growth
- formation
- formation in
- cell viability
- molecular cleavage in
- colony formation by
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- Cytoplasm
- perinuclear region
- vesicles
- microtubules
- cytosol
- vesicle membrane
- nucleoplasm
- cellular protrusions
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cse1l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into nucleus
- protein export from nucleus
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding
- nuclear export signal receptor activity