RNF20 Gene Summary [Human]
The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]
Details
| Type | Protein Coding |
| Official Symbol | RNF20 |
| Official Name | ring finger protein 20 [Source:HGNC Symbol;Acc:HGNC:10062] |
| Ensembl ID | ENSG00000155827 |
| Bio databases IDs | |
| Aliases | ring finger protein 20, BRE1 E3 ubiquitin ligase homolog (S. cerevisiae) |
| Synonyms | 4833430L21Rik, BRE1, BRE1A, hBRE1, mKIAA4116, RING FINGER protein 20 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- histone binding
- transcription co-activator
- ubiquitin protein ligase activity
- chromatin binding
- enzyme
- p53 binding
- protein binding
- identical protein binding
- RecF/RecN/SMC N terminal domain
- mRNA 3' UTR binding
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- congenital heart disease
- glioblastoma
- glioblastoma cancer
- aspermatogenesis
role in cell
- expression in
- proliferation
- activation in
- migration
- apoptosis
- formation
- formation in
- differentiation
- breakage
- olaparib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- protein polyubiquitination
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of cell migration
- regulation of mitotic cell cycle
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- nucleolus
- HULC complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- identical protein binding
- p53 binding
- ubiquitin protein ligase binding
- protein binding
- transcription coactivator activity
- metal ion binding
- histone binding
- chromatin binding
- mRNA 3'-UTR binding