Ppme1 Gene Summary [Mouse]
Enables lncRNA binding activity. Involved in protein phosphorylation. Is expressed in several structures, including alimentary system; clavicle; ganglia; lower urinary tract; and nasal cavity epithelium. Orthologous to human PPME1 (protein phosphatase methylesterase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppme1 |
| Official Name | protein phosphatase methylesterase 1 [Source:MGI Symbol;Acc:MGI:1919840] |
| Ensembl ID | ENSMUSG00000030718 |
| Bio databases IDs | |
| Aliases | protein phosphatase methylesterase 1 |
| Synonyms | 1110069N17Rik, 2700017M01Rik, ABDH19, PME-1, protein phosphatase methylesterase 1, RGD1309683 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppme1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carboxylic ester hydrolase
- protein phosphatase inhibitor activity
- alpha/beta hydrolase fold
- protein kinase binding
- alpha/beta hydrolases
- Alpha/beta hydrolase family
- protein phosphatase binding
- protein phosphatase regulator
- enzyme
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- psoriasis
- astrocytoma
- glioma formation
- cognitive impairment
role in cell
- phosphorylation in
- phagocytosis by
- dephosphorylation in
- G2/M phase transition
- long-term potentiation in
- capivasertib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppme1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G2/M transition of mitotic cell cycle
- protein demethylation
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein phosphatase inhibitor activity
- protein phosphatase binding
- protein binding
- cadherin binding
- protein methylesterase activity
- protein phosphatase 2A binding
- protein phosphatase regulator activity
- protein C-terminal methylesterase activity