Xpc

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and damaged DNA binding activity. Involved in UV-damage excision repair and nucleotide-excision repair. Acts upstream of or within mitotic intra-S DNA damage checkpoint signaling; pyrimidine dimer repair by nucleotide-excision repair; and response to UV-B. Located in nucleus. Is active in site of DNA damage. Is expressed in embryo. Used to study lung cancer and xeroderma pigmentosum group C. Human ortholog(s) of this gene implicated in pancreatic cancer; serous cystadenocarcinoma; xeroderma pigmentosum; and xeroderma pigmentosum group C. Orthologous to human XPC (XPC complex subunit, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Xpc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Xpc gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Xpc gene, providing context for its role in the cell.