Dctn3 Gene Summary [Mouse]
Acts upstream of or within microtubule-based process. Part of dynactin complex. Orthologous to human DCTN3 (dynactin subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dctn3 |
| Official Name | dynactin 3 [Source:MGI Symbol;Acc:MGI:1859251] |
| Ensembl ID | ENSMUSG00000028447 |
| Bio databases IDs | |
| Aliases | dynactin 3 |
| Synonyms | DCTN-22, dynactin 3, dynactin subunit 3, p24 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dctn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dynactin subunit p22
- protein binding
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bullous pemphigoid
regulates
- motor
- dynein intermediate chain
- dynein heavy chain
- LIC
- dynein light chain
role in cell
- binding in
- cell death
- binding
- metaphase
- translocation
- impairment in
- alignment in
- impairment
- translocation in
- motor function in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- centrosome
- microtubules
- cytosol
- nucleoli
- mitotic spindle
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dctn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle
- microtubule-based process
Cellular Component
Where in the cell the gene product is active
- centrosome
- perinuclear region of cytoplasm
- dynactin complex
- cleavage furrow
- spindle
- cytosol
- midbody
- kinetochore
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity