Unc13b Gene Summary [Mouse]
Predicted to enable GTP-dependent protein binding activity; calmodulin binding activity; and syntaxin-1 binding activity. Involved in several processes, including positive regulation of defense response to bacterium; regulated exocytosis; and regulation of synaptic plasticity. Acts upstream of or within chemical synaptic transmission; innervation; and neuromuscular junction development. Located in several cellular components, including early phagosome; presynaptic active zone; and ribbon synapse. Is active in calyx of Held; glutamatergic synapse; and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Orthologous to human UNC13B (unc-13 homolog B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Unc13b |
| Official Name | unc-13 homolog B [Source:MGI Symbol;Acc:MGI:1342278] |
| Ensembl ID | ENSMUSG00000028456 |
| Bio databases IDs | |
| Aliases | unc-13 homolog B |
| Synonyms | LOC108168936, MUNC13, Munc13-1, Munc13-2, UNC13, Unc13a, Unc13h1, Unc13h2, unc-13 homolog B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Unc13b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP-dependent protein binding
- calmodulin binding
- syntaxin-1 binding
- protein kinase C conserved region 1 (C1 domain) superfamily
- protein binding
- Protein kinase C conserved region 2 (CalB)
- non-kinase phorbol ester receptor
- MUN domain
- syntaxin binding
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- Parkinson disease
- COVID-19
- cerebral cavernous malformation
role in cell
- fusion
- fusion in
- exocytosis
- disruption
- apoptosis
- disruption in
- development
- abnormal quantity
- electrophysiology
- priming
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- presynaptic active zone
- glutaminergic synapse
- presynaptic regions
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- cytosol
- presynaptic membrane
- synaptic membrane
- neuromuscular junctions
- synapse
- synaptic-like microvesicles
- axon terminals
- presynaptic terminals
- ribbon synapse
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Unc13b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of synaptic vesicle priming
- synaptic vesicle docking involved in exocytosis
- synaptic vesicle priming
- cellular response to glucose stimulus
- positive regulation of apoptotic process
- synaptic transmission
- positive regulation of protein secretion
- positive regulation of inhibitory postsynaptic membrane potential
- acrosomal vesicle exocytosis
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- presynaptic active zone
- terminal button
- membrane
- cytosol
- Golgi apparatus
- neuromuscular junction
- synaptic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- syntaxin-1 binding
- calcium ion binding
- small GTPase binding
- diacylglycerol binding
- phospholipid binding
- GTP-dependent protein binding