Calm2 Gene Summary [Mouse]
Enables calcium-dependent protein binding activity. Involved in negative regulation of calcium ion export across plasma membrane; negative regulation of calcium ion transmembrane transporter activity; and presynaptic endocytosis. Acts upstream of or within G2/M transition of mitotic cell cycle and regulation of calcium-mediated signaling. Located in membrane; myelin sheath; and vesicle. Part of voltage-gated potassium channel complex. Is active in calyx of Held and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; heart; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in long QT syndrome 15. Orthologous to human CALM2 (calmodulin 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Calm2 |
| Official Name | calmodulin 2 [Source:MGI Symbol;Acc:MGI:103250] |
| Ensembl ID | ENSMUSG00000036438 |
| Bio databases IDs | |
| Aliases | calmodulin 2 |
| Synonyms | 1500001E21RIK, CALM, CALML2, calmodulin 2, Cam, CAM1, Cam2, CAM3, Camb, CAMC, CAMII, CAMIII, LQT15, PHKD, PHKD2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Calm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein-coupled receptor binding
- protein phosphatase regulator
- Ca2+ insensitive EF hand
- EFh_MICU
- enzyme activator activity
- EFh_PI-PLC
- EF-hand domain
- cytoskeletal protein binding
- nitric oxide synthase regulator
- EF hand
- ion channel binding
- calcium-dependent protein binding
- EF-hand, calcium binding motif
- calcium channel inhibitor
- protein kinase binding
- EF-hand domain pair
- enzyme binding
- calcium ion binding
- EFh
- protein domain specific binding
- enzyme regulator activity
- protein binding
- receptor binding
- calcium channel regulator
- protein kinase activator
- phosphoinositide 3-kinase binding
- adenylate cyclase binding
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- phosphatase activator
Pathways
Biological processes and signaling networks where the Calm2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic kidney disease
- long QT syndrome 1
- long QT syndrome type 15
- long-QT syndrome
- catecholaminergic polymorphic ventricular tachycardia
- myopia
- sudden infant death syndrome
role in cell
- binding in
- transcription in
- G2/M phase transition
- cytokinesis in
- endocytosis
- exocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- cellular membrane
- Plasma Membrane
- vesicles
- centrosome
- sarcomere
- cytosol
- mitochondrial membrane
- nucleoplasm
- spindle pole
- spindle fibers
- synaptic vesicles
- growth cone
- myelin sheath
- synapse
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Calm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- G-protein coupled receptor signaling pathway
- positive regulation of ryanodine-sensitive calcium-release channel activity
- substantia nigra development
- negative regulation of ryanodine-sensitive calcium-release channel activity
- detection of calcium ion
- regulation of heart rate
- positive regulation of cyclic-nucleotide phosphodiesterase activity
- positive regulation of protein autophosphorylation
- G2/M transition of mitotic cell cycle
- positive regulation of phosphoprotein phosphatase activity
- negative regulation of peptidyl-threonine phosphorylation
- response to calcium ion
- regulation of cytokinesis
- regulation of calcium-mediated signaling
- positive regulation of peptidyl-threonine phosphorylation
- positive regulation of protein dephosphorylation
- positive regulation of protein serine/threonine kinase activity
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- regulation of cardiac muscle contraction
Cellular Component
Where in the cell the gene product is active
- myelin sheath
- voltage-gated potassium channel complex
- spindle pole
- plasma membrane
- nucleus
- spindle microtubule
- centrosome
- calcium channel complex
- sperm midpiece
- cytoplasm
- membrane
- vesicle
- macromolecular complex
- sarcomere
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein serine/threonine kinase activator activity
- protein binding
- adenylate cyclase activator activity
- protein phosphatase activator activity
- calcium ion binding
- calcium-dependent protein binding
- titin binding
- adenylate cyclase binding
- ion channel binding
- calcium channel inhibitor activity