Unc13b Gene Summary [Rat]
Enables calmodulin binding activity and syntaxin-1 binding activity. Involved in several processes, including positive regulation of inhibitory postsynaptic potential; regulation of secretion by cell; and secretion by cell. Located in cytosol; synaptic membrane; and terminal bouton. Orthologous to human UNC13B (unc-13 homolog B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Unc13b |
| Official Name | unc-13 homolog B [Source:RGD Symbol;Acc:619723] |
| Ensembl ID | ENSRNOG00000008237 |
| Bio databases IDs | |
| Aliases | unc-13 homolog B |
| Synonyms | LOC108168936, MUNC13, Munc13-1, Munc13-2, UNC13, Unc13a, Unc13h1, Unc13h2, unc-13 homolog B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Unc13b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP-dependent protein binding
- calmodulin binding
- syntaxin-1 binding
- protein kinase C conserved region 1 (C1 domain) superfamily
- protein binding
- Protein kinase C conserved region 2 (CalB)
- non-kinase phorbol ester receptor
- MUN domain
- syntaxin binding
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- Parkinson disease
- COVID-19
- cerebral cavernous malformation
role in cell
- fusion
- fusion in
- exocytosis
- disruption
- apoptosis
- disruption in
- development
- abnormal quantity
- electrophysiology
- priming
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- presynaptic active zone
- glutaminergic synapse
- presynaptic regions
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- cytosol
- presynaptic membrane
- synaptic membrane
- neuromuscular junctions
- synapse
- synaptic-like microvesicles
- axon terminals
- presynaptic terminals
- ribbon synapse
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Unc13b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of synaptic vesicle priming
- synaptic vesicle docking involved in exocytosis
- synaptic vesicle priming
- cellular response to glucose stimulus
- positive regulation of apoptotic process
- synaptic transmission
- positive regulation of protein secretion
- positive regulation of inhibitory postsynaptic membrane potential
- acrosomal vesicle exocytosis
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- presynaptic active zone
- terminal button
- membrane
- cytosol
- Golgi apparatus
- neuromuscular junction
- synaptic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- syntaxin-1 binding
- calcium ion binding
- small GTPase binding
- diacylglycerol binding
- phospholipid binding
- GTP-dependent protein binding