Plpp3 Gene Summary [Mouse]
Enables integrin binding activity and sphingosine-1-phosphate phosphatase activity. Involved in positive regulation of endothelial cell-matrix adhesion via fibronectin; positive regulation of intracellular signal transduction; and protein stabilization. Acts upstream of or within several processes, including Bergmann glial cell differentiation; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of signal transduction. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human PLPP3 (phospholipid phosphatase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plpp3 |
| Official Name | phospholipid phosphatase 3 [Source:MGI Symbol;Acc:MGI:1915166] |
| Ensembl ID | ENSMUSG00000028517 |
| Bio databases IDs | |
| Aliases | phospholipid phosphatase 3 |
| Synonyms | 1110003O22RIK, 2610002D05Rik, D4Bwg0538e, D4Bwg1535e, DRI42, Locuslink 68448, LPP3, PAP2B, PAP2-beta, PAP2-β, Phosphatidate phosphatase 2b, phospholipid phosphatase 3, Ppab2b, PPAP2B, PRG-2, VCIP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plpp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acid phosphatase homologues
- lipid phosphatase
- PAP2 superfamily
- sphingosine-1-phosphate phosphatase
- phosphatidate phosphatase
- integrin binding
- phosphatase
- RGD motif
- extracellular loop
- enzyme
- protein binding
- PAP2_like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- metabolic syndrome X
- myocardial infarction
- endometriosis
- angina pectoris
- coronary artery disease
- growth failure
- bleeding
- diabetic nephropathy
- wheeze
role in cell
- expression in
- activation in
- phosphorylation in
- binding in
- differentiation
- migration
- adhesion
- tumorigenicity
- aggregation
- destabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- detergent-insoluble fractions
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- basolateral membrane
- trans Golgi network
- membrane rafts
- cell-cell adherens junctions
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plpp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid dephosphorylation
- signal transduction
- retrograde vesicle-mediated transport, Golgi to ER
- sphingosine metabolic process
- Bergmann glial cell differentiation
- positive regulation of cell-cell adhesion
- ceramide metabolic process
- phospholipid metabolic process
- positive regulation of sequence-specific DNA binding transcription factor activity
- integrin-mediated signaling pathway
- wound healing
- blood vessel development
- gastrulation with mouth forming second
- negative regulation of protein phosphorylation
- cell-cell adhesion mediated by integrin
- regulation of Wnt receptor signaling pathway
- protein stabilization
- homotypic cell-cell adhesion
- positive regulation of endothelial cell migration
- positive regulation of peptidyl-tyrosine phosphorylation
- sphingolipid catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- trans-Golgi network
- adherens junction
- membrane
- membrane raft
- Golgi membrane
- endoplasmic reticulum exit site
- Golgi apparatus
- basolateral plasma membrane
- plasma membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidate phosphatase activity
- protein binding
- sphingosine-1-phosphate phosphatase activity
- integrin binding