Dnajc6 Gene Summary [Mouse]
Predicted to enable clathrin heavy chain binding activity and heat shock protein binding activity. Involved in clathrin-dependent endocytosis and synaptic vesicle uncoating. Acts upstream of or within clathrin coat disassembly and regulation of clathrin-dependent endocytosis. Located in postsynaptic density. Is extrinsic component of presynaptic endocytic zone membrane. Is expressed in genital tubercle of male; gut; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 19A. Orthologous to human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnajc6 |
| Official Name | DnaJ heat shock protein family (Hsp40) member C6 [Source:MGI Symbol;Acc:MGI:1919935] |
| Ensembl ID | ENSMUSG00000028528 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member C6 |
| Synonyms | 2810027M23Rik, Auxilin, DJC6, DnaJ heat shock protein family (Hsp40) member C6, mKIAA0473, PARK19 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnajc6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- heat shock protein binding
- C2 domain of PTEN tumour-suppressor protein
- clathrin binding
- protein binding
- PTP_DSP_cys
Pathways
Biological processes and signaling networks where the Dnajc6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- juvenile-onset Parkinson disease type 19A
- androgenic alopecia
- idiopathic femoral head osteonecrosis
- dementia
- early-onset Parkinson disease
- combined cerebellar and peripheral ataxia with hearing loss and diabetes mellitus
regulates
- Clathrin
role in cell
- production in
- abnormal quantity
- recycling
- uncoating
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- synapse
- postsynaptic density
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnajc6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- clathrin-mediated endocytosis
- synaptic vesicle uncoating
- intracellular transport
- regulation of clathrin-mediated endocytosis
- clathrin coat disassembly
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- cytoplasm
- intracellular membrane-bounded organelle
- vesicle
- cytosol
- clathrin-coated vesicle
Molecular Function
What the gene product does at the molecular level
- clathrin heavy chain binding
- heat shock protein binding
- protein binding
- protein tyrosine phosphatase activity
- SH3 domain binding
- clathrin binding