Synj1

Enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in regulation of postsynaptic neurotransmitter receptor internalization and synaptic vesicle uncoating. Acts upstream of or within several processes, including phosphatidylinositol dephosphorylation; synaptic vesicle cycle; and synaptic vesicle transport. Part of membrane coat. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; peripheral nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 20; and developmental and epileptic encephalopathy 53. Orthologous to human SYNJ1 (synaptojanin 1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Synj1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Synj1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Synj1 gene, providing context for its role in the cell.