Tox Gene Summary [Mouse]
Enables chromatin DNA binding activity. Involved in several processes, including alpha-beta T cell lineage commitment; cerebral cortex neuron differentiation; and regulation of positive thymic T cell selection. Acts upstream of or within hematopoietic or lymphoid organ development; lymphocyte differentiation; and positive regulation of natural killer cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human TOX (thymocyte selection associated high mobility group box). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tox |
| Official Name | thymocyte selection-associated high mobility group box [Source:MGI Symbol;Acc:MGI:2181659] |
| Ensembl ID | ENSMUSG00000041272 |
| Bio databases IDs | |
| Aliases | thymocyte selection-associated high mobility group box |
| Synonyms | 1700007F02Rik, KIAA0808, thymocyte selection-associated high mobility group box, Thymocyte selection-associated HMG box, TOX1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tox often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- high mobility group (HMG)-box domain superfamily
- HMG (high mobility group) box
- high mobility group
- chromatin binding
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- pneumonia
- Wegener granulomatosis
- precursor B-cell acute lymphoblastic leukemia
- neoplasia
- insulin-dependent diabetes mellitus
- cannabis dependence
- insomnia
- organismal death
- idiopathic scoliosis
role in cell
- activation in
- expression in
- proliferation
- differentiation
- quantity
- apoptosis
- cell viability
- number
- growth
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tox gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- CD8-positive, alpha-beta T cell lineage commitment
- lymph node development
- CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
- positive regulation of transcription from RNA polymerase II promoter
- chromatin organization
- NK T cell lineage commitment
- cerebral cortex neuron differentiation
- regulation of transcription from RNA polymerase II promoter
- positive regulation of natural killer cell differentiation
- leukocyte differentiation
- natural killer cell differentiation
- CD4-positive, alpha-beta T cell lineage commitment
- Peyer's patch development
- positive regulation of neural precursor cell proliferation
- positive regulation of neuron projection development
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- protein binding