Cmpk1 Gene Summary [Mouse]
Predicted to enable CMP kinase activity; UMP kinase activity; and nucleoside diphosphate kinase activity. Predicted to be involved in pyrimidine nucleoside diphosphate biosynthetic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including heart; nervous system; respiratory system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CMPK1 (cytidine/uridine monophosphate kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cmpk1 |
| Official Name | cytidine monophosphate (UMP-CMP) kinase 1 [Source:MGI Symbol;Acc:MGI:1913838] |
| Ensembl ID | ENSMUSG00000028719 |
| Bio databases IDs | |
| Aliases | cytidine monophosphate (UMP-CMP) kinase 1 |
| Synonyms | 0610011D08Rik, CK, CMK, CMPK, cytidine/uridine monophosphate kinase 1, RGD1310116, UMK, UMP-CMPK, UMPK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cmpk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside diphosphate kinase
- adenylate kinase, isozyme 1 subfamily
- UMP kinase
- protein binding
- AAA domain
- kinase
- dTMP kinase
- adenylate kinase
- nucleoside-phosphate kinase
- uridine kinase
- NK
- cytidylate kinase
- uridylate kinase
- UMP-CMP kinase family
- N-terminal helicase domain of the DEAD-box helicase superfamily
- Thymidylate kinase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nausea
- migraines
regulates
- SLC2A4
- beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluoro-CMP
- nitrogenous base
- nucleotide
- nucleoside
- gemcitabine monophosphate
- beta-D-2',3'-dideoxy-CMP
- beta-L-dioxolane-CMP
- beta-L-2',3'-dideoxy-CMP
- 1-beta-D-arabinofuranosylcytosine 5'-monophosphate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cmpk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- CDP biosynthetic process
- 'de novo' pyrimidine base biosynthetic process
- pyrimidine ribonucleotide biosynthetic process
- nucleobase-containing small molecule interconversion
- UMP biosynthetic process
- nucleoside monophosphate phosphorylation
- UDP biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleoside phosphate kinase activity
- ATP binding
- cytidylate kinase activity
- uridine kinase activity
- UMP kinase activity
- nucleoside diphosphate kinase activity