Slc66a1 Gene Summary [Mouse]
Predicted to enable L-arginine transmembrane transporter activity; L-histidine transmembrane transporter activity; and L-lysine transmembrane transporter activity. Predicted to be involved in L-amino acid transport and intracellular amino acid homeostasis. Predicted to be located in intracellular membrane-bounded organelle and organelle membrane. Predicted to be active in lysosomal membrane. Is expressed in embryo. Orthologous to human SLC66A1 (solute carrier family 66 member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Slc66a1 |
| Official Name | solute carrier family 66 member 1 [Source:MGI Symbol;Acc:MGI:2384837] |
| Ensembl ID | ENSMUSG00000028744 |
| Bio databases IDs | |
| Aliases | solute carrier family 66 member 1 |
| Synonyms | BC019216, LAAT-1, PQLC2, solute carrier family 66 member 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc66a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- organic cation transporter
- SWEET
- lysine transporter
- Sugar efflux transporter for intercellular exchange
- L-amino acid transporter
- protein binding
- basic amino acid transporter
- PQ loop repeat
- histidine transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc66a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- lysine transport
- amino acid homeostasis
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- organelle membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- L-histidine transmembrane transporter activity
- L-lysine transmembrane transporter activity
- basic amino acid transmembrane transporter activity