Gjc1 Gene Summary [Mouse]
Enables gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling and monoatomic ion channel activity. Involved in AV node cell to bundle of His cell communication by electrical coupling and gap junction assembly. Acts upstream of or within several processes, including chemical synaptic transmission; circulatory system development; and visual perception. Located in gap junction. Part of connexin complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and heart. Orthologous to human GJC1 (gap junction protein gamma 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gjc1 |
| Official Name | gap junction protein, gamma 1 [Source:MGI Symbol;Acc:MGI:95718] |
| Ensembl ID | ENSMUSG00000034520 |
| Bio databases IDs | |
| Aliases | gap junction protein, gamma 1 |
| Synonyms | C130009G16Rik, Cnx45, Connexin 45, CX45, Cxnq, gap junction protein gamma 1, gap junction protein, gamma 1, gap junction protein γ 1, gap junction protein, γ 1, GJA7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gjc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Connexin homologues
- Gap junction channel protein cysteine-rich domain
- protein binding
- ion channel
- Connexin
- gap-junction forming channel
Pathways
Biological processes and signaling networks where the Gjc1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- expression in
- proliferation
- apoptosis
- segregation
- assembly
- formation
- development
- activation in
- development in
- firing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- perinuclear region
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- intercellular junctions
- endoplasmic reticulum membrane
- nucleoplasm
- intercalated disks
- gap junction plaques
- gap junctions
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gjc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of atrial cardiac muscle cell action potential
- cell-cell junction assembly
- ion transmembrane transport
- cell-cell signaling
- synaptic transmission
- vasculogenesis
- cell development
- visual perception
- cardiac muscle tissue development
- muscle contraction
- gap junction assembly
- AV node cell to bundle of His cell communication by electrical coupling
- SA node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- gap junction
- connexon complex
- intercalated disc
- endoplasmic reticulum
- synapse
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ion channel activity
- gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
- protein binding
- gap junction channel activity
- gap junction channel activity involved in SA node cell-atrial cardiomyocyte electrical coupling