Ptges Gene Summary [Mouse]
Enables prostaglandin-D synthase activity and prostaglandin-E synthase activity. Involved in cyclooxygenase pathway; regulation of fever generation; and sensory perception of pain. Acts upstream of or within negative regulation of cell population proliferation; positive regulation of prostaglandin secretion; and prostaglandin metabolic process. Located in endoplasmic reticulum membrane and nuclear envelope lumen. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human PTGES (prostaglandin E synthase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptges |
| Official Name | prostaglandin E synthase [Source:MGI Symbol;Acc:MGI:1927593] |
| Ensembl ID | ENSMUSG00000050737 |
| Bio databases IDs | |
| Aliases | prostaglandin E synthase |
| Synonyms | 2410099E23Rik, CPGES, D2Ertd369e, MGST1-L1, MGST-IV, MPGES, MPGES-1, PGES, PGES1, PIG12, PP102, PP1294, prostaglandin E synthase, PTGES1, TP53I12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptges often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- glutathione transferase
- MAPEG family
- enzyme
- protein binding
- Glutathione acceptor domain
- glutathione peroxidase
- prostaglandin-D synthase
- prostaglandin-E synthase
Pathways
Biological processes and signaling networks where the Ptges gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- neoplasia
- experimental autoimmune encephalomyelitis
- organismal death
- rheumatoid arthritis
- diastolic dysfunction
- serous ovarian cancer
- chronic inflammation
- abdominal aortic aneurysm
- non-small cell lung carcinoma
role in cell
- accumulation in
- expression in
- proliferation
- quantity
- apoptosis
- colony formation
- number
- cellular infiltration by
- hypertrophy
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- lipid-rich fraction
- perinuclear membrane
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- perinuclear space
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptges gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of prostaglandin secretion
- cell proliferation
- signal transduction
- negative regulation of cell proliferation
- prostaglandin biosynthetic process
- sensory perception of pain
- regulation of inflammatory response
- prostaglandin metabolic process
- regulation of fever generation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- membrane
- nuclear envelope lumen
Molecular Function
What the gene product does at the molecular level
- prostaglandin-D synthase activity
- protein binding
- glutathione peroxidase activity
- glutathione binding
- prostaglandin-E synthase activity
- glutathione transferase activity