Add1 Gene Summary [Mouse]
A structural constituent of cytoskeleton. Involved in cellular response to calcium ion; positive regulation of adherens junction organization; and positive regulation of establishment of endothelial barrier. Acts upstream of or within several processes, including cell volume homeostasis; erythrocyte differentiation; and hemoglobin metabolic process. Located in adherens junction; cytoskeleton; and membrane. Is active in synapse. Colocalizes with plasma membrane. Is expressed in several structures, including brain; brown fat; liver; lung; and spleen. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Orthologous to human ADD1 (adducin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Add1 |
| Official Name | adducin 1 (alpha) [Source:MGI Symbol;Acc:MGI:87918] |
| Ensembl ID | ENSMUSG00000029106 |
| Bio databases IDs | |
| Aliases | adducin 1 (alpha) |
| Synonyms | ADDA, adducin 1, Adducin 1 alpha, Adducin 1 α, alpha ADDUCIN, α ADDUCIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Add1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- T-cell receptor binding
- spectrin binding
- transcription factor binding
- protein binding
- phosphorylation site
- actin filament binding
- Aldolase_II
- structural constituent of cytoskeleton
- Class II Aldolase and Adducin N-terminal domain
- actin binding
- protein homodimerization
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Add1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hemolytic anemia
- Parkinson disease
- Huntington disease
- migraines
- spherocytosis
- salt-sensitive essential hypertension
- communicating hydrocephalus
- thrombocytosis
- essential hypertension
role in cell
- expression in
- adhesion
- quantity
- assembly
- migration
- differentiation
- abnormal morphology
- curvature
- ruffling
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cortical actin cytoskeleton
- cytoskeleton
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- cell-cell contacts
- cytosol
- lateral plasma membrane
- nucleoplasm
- nuclear bodies
- dendritic spines
- synapse
- cell membrane leading edge
- dendrites
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Add1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- barbed-end actin filament capping
- positive regulation of protein binding
- cellular response to calcium ion
- actin cytoskeleton organization
- actin filament bundle assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- postsynaptic density
- adherens junction
- nuclear body
- cytoskeleton
- focal adhesion
- cytoplasm
- cytosol
- F-actin capping protein complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- calmodulin binding
- RNA binding
- protein homodimerization activity
- protein binding
- actin binding
- spectrin binding
- protein heterodimerization activity
- cadherin binding
- protein dimerization activity