Prokr2 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor activity. Acts upstream of or within circadian rhythm. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; hemolymphoid system gland; nose; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 3 with or without anosmia. Orthologous to human PROKR2 (prokineticin receptor 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prokr2 |
| Official Name | prokineticin receptor 2 [Source:MGI Symbol;Acc:MGI:2181363] |
| Ensembl ID | ENSMUSG00000050558 |
| Bio databases IDs | |
| Aliases | prokineticin receptor 2 |
| Synonyms | B830005M06Rik, dJ680N4.3, EG-VEGFR2, EG-VEGRF2, Gpcr73l1, GPR73b, GPR73L1, GPRg2, HH3, KAL3, PKR2, prokineticin receptor 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prokr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Kallmann syndrome type 3
- hypogonadotropic hypogonadism 3
- cancer
- hypogonadotropic hypogonadism 3 without anosmia
- hypogonadotropic hypogonadism 7
- hypoplasia
- hereditary disorder
- hypogonadotropic hypogonadism
- hypogonadotropic hypogonadism 2 without anosmia
- Kallmann syndrome
role in cell
- growth
- activation in
- outgrowth
- surface area
- cisplatin sensitivity
- abnormal morphology
- recruitment in
- accumulation in
- release in
- permeability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prokr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
- circadian rhythm
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- neuropeptide Y receptor activity