Ube4b Gene Summary [Mouse]
Enables ATP binding activity; enzyme binding activity; and ubiquitin-ubiquitin ligase activity. Acts upstream of or within several processes, including protein ubiquitination; ubiquitin-dependent protein catabolic process; and ventricular trabecula myocardium morphogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human UBE4B (ubiquitination factor E4B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube4b |
| Official Name | ubiquitination factor E4B [Source:MGI Symbol;Acc:MGI:1927086] |
| Ensembl ID | ENSMUSG00000028960 |
| Bio databases IDs | |
| Aliases | ubiquitination factor E4B |
| Synonyms | 4930551I19Rik, 4933406G05Rik, D4Bwg0973e, E4, HDNB1, KIAA0684, LOC100041794, mKIAA0684, Ubiquitination factor E4B, UBOX3, UFD2, UFD2A, Ufd2p |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube4b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Modified RING finger domain
- ATP binding
- enzyme binding
- enzyme
- protein binding
- Ubiquitin elongating factor core
Pathways
Biological processes and signaling networks where the Ube4b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- neurodegeneration
- neuroaxonal dystrophy
- bleeding
- hyperleptinemia
- gait disturbance
- insulin resistance
- hypercholesterolemia
- congestive heart failure
- ataxia
role in cell
- expression in
- activation in
- growth
- apoptosis
- number
- JG-231 sensitivity
- extension
- quantity
- formation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube4b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- induction of apoptosis by granzyme
- protein polyubiquitination
- response to UV
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-ubiquitin ligase activity
- enzyme binding