Sf3b4 Gene Summary [Mouse]

This gene encodes one of the subunits of splicing factor 3B. A similar gene in human encodes a protein that cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes, and also belongs with the minor U12-dependent spliceosome. [provided by RefSeq, May 2015]

Details

Type
Protein Coding
Official Symbol
Sf3b4
Official Name
splicing factor 3b, subunit 4 [Source:MGI Symbol;Acc:MGI:109580]
Ensembl ID
ENSMUSG00000068856
Bio databases IDs NCBI: 107701 Ensembl: ENSMUSG00000068856
Aliases splicing factor 3b, subunit 4
Synonyms AFD1, Hsh49, SAP49, SF3b49, SF3b50, SPLICING FACTOR 3B subunit4, splicing factor 3b, subunit 4
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sf3b4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RNA recognition motif (RRM) superfamily
  • RNA recognition motif
  • protein binding

Pathways

Biological processes and signaling networks where the Sf3b4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • cancer
  • epithelial neoplasia
  • epithelial cancer
  • lung adenocarcinoma formation
  • Nager syndrome
  • acute myeloid leukemia
  • brain glioma
  • brain glioma formation
  • head and neck squamous cell carcinoma
  • head and neck squamous cell cancer
regulated by
regulates
role in cell
  • proliferation
  • expression in
  • differentiation
  • migration
  • cell proliferation
  • dipeptide repeat protein sensitivity
  • invasion by
  • splicing by
  • Clathrin mediated endocytosis by
  • alternative splicing in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nuclear fraction
  • Plasma Membrane
  • spliceosomes
  • nucleoplasm
  • interchromatin granule clusters
  • nuclear speckles

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Sf3b4 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • RNA splicing, via transesterification reactions
  • RNA splicing
  • positive regulation of nuclear mRNA splicing, via spliceosome
  • mRNA processing
  • nuclear mRNA splicing, via spliceosome

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • U12-type spliceosomal complex
  • spliceosomal complex
  • U2-type spliceosomal complex
  • U2-type precatalytic spliceosome
  • U2 snRNP
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • RNA binding
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.